Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 4:57 AM
Ignite Modification Date:
2025-12-25 @ 4:57 AM
NCT ID:
NCT01823718
Eligibility Criteria:
Inclusion Criteria:
* Male or female, without immunosuppressed organ transplant or immunocompromised and who received a kidney transplant, or kidney-pancreas, or heart or lung or heart-lung, or liver, or cells hematopoietic stem cells, and has given its consent
* Aged 18 to 75 years Children aged more than 12 months,
* PS \<4
* Viral load determined EBV
* Life expectancy\> 1 month
* Patient typed for HLA DP DQ DR ABC
* Patients with lymphoma in the immunosuppressed associated with EBV and failure, partial response (\<50%) or relapsed after treatment with monoclonal antibodies and / or chemotherapy completed for at least three weeks. Patients with partial response may have a PET scan to confirm the lack of response.
* Patient with a measurable mass to assess the response or bone marrow infiltration and / or measurable blood and having frozen tumor material or having a repeat biopsy.
* Availability of a CTL matching at least two HLA or one HLA after validation experts with tumor cells
* test de cytotoxicity negative
Exclusion Criteria:
* Patient Pregnant or lactating
* Concurrent infection with HIV
* EBV negative lymphomas
* If acute GVHD\> grade II J-1 before injection (case grafts CSH)
* Treatment of molecules in pre-marketing authorization older than 21 days
* No matching at least two CTL HLA or non expert validation for the use of CTL with HLA sharing a single tumor
* Test of cytotoxicity positive
* Lack of recognition of tumor cells when available
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
12 Months
Study:
NCT01823718
Study Brief:
Protocol Section:
NCT01823718