Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 4:55 AM
Ignite Modification Date:
2025-12-25 @ 4:55 AM
NCT ID:
NCT04103918
Eligibility Criteria:
Inclusion Criteria:
1. Men or women with age \> 35 and ≤ 65 years.
2. Subjects with facial and neck wrinkles, seeking tissue augmentation treatment and willing to receive HA Filler;
3. Subjects presenting a score of 2 (shallow wrinkles) or 3 (moderate, deep wrinkles) on the Wrinkles Severity Ranking Scale (WSRS);
4. Subjects who agree to discontinue all dermatological treatment and procedures during the study.
5. Subjects willing to provide signed informed consent to clinical investigation participation.
6. Able to communicate adequately with the Investigator and to comply with the requirements for the entire study.
Exclusion Criteria:
1. Use of aspirin and antiplatelet agents a week prior to treatment;
2. Pregnant or lactating women;
3. Subjects with history of allergy or hypersensitivity to the HA or to other ingredients of the dermal filler;
4. Subjects with hypersensitivity to salicylic acid or any of its derivates;
5. Subjects with any dermal systemic pathologies, such as systemic lupus erythematosus, psoriasis, scleroderma etc.;
6. Subjects presenting bleeding disorders in the past or present;
7. Hypersensitivity skin reaction to the investigational device based on intradermal test results at baseline.
8. Subjects taking or having indications for anticoagulant therapy;
9. Use of concomitant treatments or procedures aimed to improve skin rejuvenation over the last six months before the clinical investigation enrolment, such as chemical peeling, dermabrasion, laser resurfacing;
10. Subjects suffering from infectious diseases including herpes simplex virus infection, active hepatitis or human immunodeficiency virus;
11. Subjects suffering from eczema, acne and keloids;
12. Subjects with any cutaneous manifested infection, disease or alteration;
13. Subjects at risk in term of precautions, warnings and contra-indications referred in the package insert of the clinical investigation device;
14. Subjects with any facial aesthetic surgery in the preceding 12 months before the clinical investigation enrolment;
15. Subjects with any active irritation or inflammation in the target areas of injection;
16. Subjects who received botulinum toxin A injections in the face in the preceding 6 months;
17. Subjects unlikely to cooperate in the clinical investigation or to comply with the treatment or with the clinical investigation visits.
18. Participation in an interventional clinical study or administration of any investigational agents in the previous 30 days.
19. Presence of any clinically significant medical condition judged by the investigator to preclude the patient's inclusion in the study
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
35 Years
Maximum Age:
65 Years
Study:
NCT04103918
Study Brief:
Protocol Section:
NCT04103918