Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 4:41 AM
Ignite Modification Date:
2025-12-25 @ 4:41 AM
NCT ID:
NCT00675818
Eligibility Criteria:
Inclusion Criteria:
1. Adult patients (over 16 years of age) admitted to a participating ICU
2. Serum creatinine increase of ≥ 50% from baseline
3. Hemodynamic instability as defined by the cardiovascular component of the SOFA score of ≥ 1
4. Attending physician deems the patient a candidate for RRT for at least one of the following reasons:
1. Presence of oliguria, defined as a urine output of \< 100 mL in the preceding 4 hours
2. metabolic acidosis (HCO3- \< 15 mmol/L and pH \< 7.25)
3. refractory hyperkalemia (K \> 6.0 mmol/L)
4. azotemia (BUN \> 50 mmol/L)
5. suspected uremic organ involvement (pericarditis, encephalopathy, neuropathy or myopathy)
Exclusion Criteria:
1. renal replacement therapy within the previous 2 months
2. presence of renal obstruction
3. receipt of a kidney transplant in the previous year
4. diagnosis of rapidly progressive glomerulonephritis, vasculitis, or acute interstitial nephritis
5. indication for intermittent hemodialysis, specifically severe hyperkalemia, dialyzable drug or toxin
6. terminal illness with associated life expectancy less than 2 months
7. patients who are moribund
8. prior enrollment in this study
9. enrollment in a competing ICU interventional study
10. no CRRT machine available
11. acute renal replacement ongoing for \> 36 hours
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
16 Years
Study:
NCT00675818
Study Brief:
Protocol Section:
NCT00675818