Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 4:30 AM
Ignite Modification Date:
2025-12-25 @ 4:30 AM
NCT ID:
NCT05965518
Eligibility Criteria:
Inclusion Criteria:
* Age 50 years and older
* Sedentary lifestyle, defined as \< 150 min/wk moderate physical activity as assessed by CHAMPS questionnaire
* Neurocognitive Impairment (as assessed using the BRACE+
* Prescribed HIV ART for ≥ 12 months, with no current use of older drugs with established mitochondrial toxicity
* Able to speak, read, and write in English
* Willingness to participate in all study procedures
Exclusion Criteria:
* Diagnosis of mitochondrial disease
* Active substance abuse or factors preventing compliance or safety
* Uncontrolled hypertension, defined as resting BP \> 150/90 mmHG
* Chronic kidney disease
* Severe cardiac disease, including NYHA Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina
* Acute myocardial infarction identified by medical history and ECG
* Pulmonary disease requiring the use of supplemental oxygen
* Poorly controlled diabetes
* Neuropsychologically Intact
* Orthopedic problems that limit ability to perform exercise
* Simultaneous participation in another intervention trial
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
50 Years
Study:
NCT05965518
Study Brief:
Protocol Section:
NCT05965518