Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 4:27 AM
Ignite Modification Date:
2025-12-25 @ 4:27 AM
NCT ID:
NCT00732420
Eligibility Criteria:
Inclusion Criteria -
* signed, written informed consent.
* at least 18 years of age.
* ECOG performance status 0 or 1.
* Subjects must have histologically or cytologically confirmed diagnosis of advanced cancer and a solid tumor malignancy that has relapsed or is refractory to standard therapy or for which there is no established therapy.
* able to swallow and retain oral medications.
* females are eligible to enter and participate in this study providing adequate established contraception is being practiced.
Exclusion Criteria
* had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C)
* received an investigational drug within 30 days or 5 half-lives (whichever is longer).
* received prior treatment with pazopanib/investigational anti-angiogenic compounds.
* presence of uncontrolled infection.
* pregnant or lactating.
* poorly controlled hypertension (SBP of ? 140 mmHg, or DBP of ? 90 mmHg.
* Class III or IV heart failure as defined by the New York Heart Association (NYHA) functional classification system.-
* arterial thrombi, myocardial infarction, admission for unstable angina, uncontrolled or symptomatic arrhythmia, cardiac angioplasty, or stenting within the last 6 months.
* any unresolved bowel obstruction or diarrhea ? Grade 1.
* received an allogeneic bone marrow transplant.
* known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to pazopanib or topotecan.
* any serious and/or unstable pre-existing medical, psychiatric, or other conditions that could interfere with subject's safety, obtaining informed consent or compliance with the study.
* psychological, familial, sociological, or geographical conditions that do not permit compliance with the protocol.
* clinical history, current alcohol or illicit drug use which, in the judgment of the investigator, would interfere with the subject's ability to comply with the dosing schedule and protocol-specified evaluations.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT00732420
Study Brief:
Protocol Section:
NCT00732420