Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 4:12 AM
Ignite Modification Date:
2025-12-25 @ 4:12 AM
NCT ID:
NCT00715520
Eligibility Criteria:
Aims 1 and 2
Inclusion Criteria:
* Normal neurological examination
* Ability to meet criteria of inclusion experiment
* Ability to give informed consent.
Exclusion Criteria:
* History or neurological or psychiatric disease
* Abnormal MRI of brain
* Abnormal neuropsychological testing
* Intake of CNS active drugs
* History of seizure disorder
* History of migraine headaches
* History of anaphylaxis or allergic reactions
* Contraindication to TMS
Aim 3:
Inclusion Criteria:
* Cerebral ischemic infarction more than 6 months prior to entering the study
* Single lesion as defined by MRI of the brain affecting the primary motor output system of the hand at a cortical (M1) level or subcortical level, or unilateral, and supratentorial in absence of history of a previous symptomatic stroke within 3 months of the current stroke
* Dense paresis of the hand for more than three days after cerebral infarction (MRC of \< 4- of wrist- and finger extension/flexion movements)
* Good functional recovery of hand function as defined by MRC of 4 or 4+ of wrist- and finger extension/flexion movements
* Ability to perform wrist extension movements
* Ability to meet criteria of inclusion experiment
* Ability to give informed consent
* Ability of TMS to elicit a measurable MEP of \> 100 μV and an increase in MEP amplitude with increasing stimulus intensity (up to 100% of MSO) of at least 20% over MEP amplitude at MT
Exclusion Criteria:
* History or neurological or psychiatric disease, including bipolar disorder
* Intake of CNS active drugs
* History of seizure disorder
* History of migraine headaches
* History of anaphylaxis or allergic reactions
* Contraindication to TMS
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
80 Years
Study:
NCT00715520
Study Brief:
Protocol Section:
NCT00715520