Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 4:09 AM
Ignite Modification Date:
2025-12-25 @ 4:09 AM
NCT ID:
NCT00151320
Eligibility Criteria:
Inclusion Criteria:
* Histologically confirmed diagnosis of diffuse large B cell or mantle cell Non-Hodgkin's Lymphoma with characteristic immunophenotypic profiles. For mantle cell: CD5(+), CD19(+) or CD20(+), cyclin D1(+), CD23(-) and CD10(-).
* Patient has not received any prior anti-cancer therapy for lymphoma
* Tumor tissue confirmed to express the CD20 antigen
* Available frozen tumor tissue(rebiopsy if needed)
* Patient has measurable disease as defined by a tumor mass \> 1.5 cm
* Patient has Stage II, III, or IV disease
* Age \> 18 years
* Absolute granulocyte count \> 1000 cells/mm3
* Platelet count \> 50,000 cells/mm3
* Creatinine \< 2.0 x ULN
* Total bilirubin \< 2.0 x ULN
Exclusion Criteria:
* Known central nervous system (CNS) involvement by lymphoma
* Known HIV disease
* Patient is pregnant or nursing
* Patient has had major surgery within the last 3 weeks
* Patient is receiving other investigational drugs
* Known peripheral neuropathy \> Grade 2
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT00151320
Study Brief:
Protocol Section:
NCT00151320