Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 4:08 AM
Ignite Modification Date:
2025-12-25 @ 4:08 AM
NCT ID:
NCT04880720
Eligibility Criteria:
Inclusion Criteria for Active RA Patients:
* Patients with rheumatoid arthritis (RA) meeting the 2010 ACR/EULAR diagnostic criteria
* Patients in inflammatory flare of RA (DAS28 \> 3.2)
* Patients who have been off biological disease-modifying antirheumatic drugs (bDMARDs) or targeted synthetic antirheumatic drugs (tsDMARDs) for RA for at least 2 weeks (except for rituximab, where a delay of at least 12 months is required)
* Conventional synthetic DMARDs (Methotrexate, Hydroxychloroquine, Leflunomide, Sulfasalazine) are allowed
* Beneficiary of a social security system
* Informed consent
Inclusion Criteria for Healthy Controls:
* Absence of chronic diseases and current infection
* Beneficiary of a social security system
* Informed consent
Inclusion Criteria for COVID-19+ Patients:
* Patients with ongoing SARS-Cov-2 infection (PCR+)
* Patients hospitalized at D7-D14 of symptoms onset
* Patients with two or more SARS-Cov-2 symptoms (including fever, cough, dyspnea, sore throat, chest pain, anosmia, diarrhea)
* Membership in or beneficiary of a social security scheme
* Collection of free and informed consent
Exclusion Criteria for All Groups:
* Subjects under 18 years of age
* HIV positive patients
* Diabetic patients
* Morbidly obese patients (BMI \> 40kg/m2)
* Use of senolytic drugs in the week prior to inclusion (azithromycin, metformin, cyclosporine, JAK inhibitors)
* Use of steroids in doses greater than 10 mg/day in the week prior to inclusion
* Subjects unable to give consent
* Pregnant, breastfeeding, or non-menopausal women not taking effective contraception
* Vulnerable subjects protected by law
* Subjects under guardianship or curatorship
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT04880720
Study Brief:
Protocol Section:
NCT04880720