Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 4:05 AM
Ignite Modification Date:
2025-12-25 @ 4:05 AM
NCT ID:
NCT00143702
Eligibility Criteria:
Inclusion Criteria:
* Be HIV-positive
* Be 18 years of age or older
* Have a viral load equal to or below 50 copies/mL
* Have been on a d4T-containing multiple drug regimen (at least three agents in total) for at least six months
* Have been on a stable ARV regimen for the three months prior to enrollment
* Have a venous lactic acid measurement above 2.1 mmol/L within the three months prior to enrollment and two consecutive measurements above 2.1 but lower than 6.0 within a two-week period of screening
* Be willing to discontinue L-carnitine and/or coenzyme Q10
* Be willing and able to provide informed consent
Exclusion Criteria:
* Pregnancy or breastfeeding
* Venous lactic acid equal to or above 6.0 mmol/L
* Previous exposure to abacavir
* Virologic rebound while on a previous regimen consisting of dual or triple nucleoside reverse transcriptase inhibitors (NRTIs)
* Use of hydroxyurea within the three months prior to enrollment
* Use of metformin
* Any acute cardiopulmonary illness or infection
* New AIDS-defining illness diagnosed within four weeks of enrollment
* Riboflavin or thiamine supplementation above 20 mg/day within 30 days prior to enrollment
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT00143702
Study Brief:
Protocol Section:
NCT00143702