Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 3:56 AM
Ignite Modification Date:
2025-12-25 @ 3:56 AM
NCT ID:
NCT00536302
Eligibility Criteria:
Inclusion Criteria:
* age \> 49 years
* chronic knee discomfort based on the affirmative response to the question "During the past 6 months, have you had any pain in the knee more than half the days of the month ?"
* WOMAC pain subscale score ≥ 1
* tibiofemoral or patellofemoral osteoarthritis on anteroposterior weight-bearing semi-flexed or lateral knee radiographs with at least one osteophyte and no significant joint-space-narrowing
* clinical examination confirming knee pain or discomfort referable to the knee joint
* prepared to refrain from use of glucosamine, chondroitin, sAME and doxycycline
* stable medication and/or supplement use
Exclusion Criteria:
* use of glucosamine, chondroitin, diacerein or doxycycline within 14 weeks prior to randomization
* serious medical conditions or impairments that, in the view of the investigator, would obstruct their participation in the trial
* individuals who are expected not to comply with the study protocol
* plan to permanently relocate from the region during the trial period
* planned knee arthroplasty in the study knee
* active pathology of confounding origin which may cause pain, extending to the knee
* pregnancy
* any contra-indication to having an MRI scan
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
49 Years
Maximum Age:
90 Years
Study:
NCT00536302
Study Brief:
Protocol Section:
NCT00536302