Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 3:53 AM
Ignite Modification Date:
2025-12-25 @ 3:53 AM
NCT ID:
NCT05906602
Eligibility Criteria:
Inclusion Criteria:
* Single, stroke \> 6 months since onset
* Residual hemiparetic gait deficits (e.g., abnormal gait pattern)
Exclusion Criteria:
* Lesions affecting the brainstem or cerebellum
* Other neurological disorders that may interfere with motor function
* Unhealed decubiti, persistent infections that may interfere with ability to perform test procedures
* Significant cognitive or communication impairment (Mini-Mental State Examination (MMSE\<21)), which could impede the understanding of the purpose of procedures of the study
* Botulinum toxin (Botox) treatments to the lower limb within the past 6 months
* Pregnant women
* Contraindications to transcranial magnetic stimulation (TMS) or ischemic conditioning (IC) (Listed below)
TMS General Exclusion Criteria:
* Previous adverse reaction to TMS
* Skull abnormalities or fractures
* Concussion within the last 6 months
* Unexplained, recurring headaches
* Implanted cardiac pacemaker
* Metal implants in the head or face
* History of seizures or epilepsy
* Use of medications that could alter cortical excitability or increase risk of seizure (e.g., antidepressants, antipsychotics, anxiolytics, anticonvulsants)
* Current pregnancy
IC General Exclusion Criteria:
* History of thrombosis (i.e., blood clots) including venous thrombosis or deep vein thrombosis (DVT).
* Blood clots in the leg, or any condition in which compression of the thigh or transient ischemia is contraindicated (i.e., open wounds in the leg, bruising, nerve damage, etc.)
* Peripheral arterial grafts in the lower extremity
* History of uncontrolled hypertension
* History of peripheral vascular disease or hematological disease
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
21 Years
Study:
NCT05906602
Study Brief:
Protocol Section:
NCT05906602