Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 3:47 AM
Ignite Modification Date:
2025-12-25 @ 3:47 AM
NCT ID:
NCT01931202
Eligibility Criteria:
Inclusion Criteria:
* Men and women aged 60-90 years
* Diagnosis with nonpsychotic Diagnostic and Statistical Manual (DSM) IV MDD
* 24-item Hamilton Rating Scale for Depression (HRSD) score ≥ 16
* Willing to and capable of providing informed consent and complying with study procedures
Exclusion Criteria:
* Current comorbid Axis I DSM IV disorder other than Nicotine Dependence, Adjustment Disorder, or Anxiety Disorder
* diagnosis of substance abuse or dependence (excluding Nicotine Dependence) within the past 12 months
* History of psychosis, psychotic disorder, mania, or bipolar disorder
* Diagnosis of probable Alzheimer's Disease, Vascular Dementia, or Parkinson's Disease
* MMSE \< 24
* HRSD suicide item \> 2 or Clinical Global Impressions (CGI)-Severity score of 7 at baseline
* history of allergic or adverse reaction to escitalopram, or non-response to adequate trial of escitalopram (at least 4 weeks at dose of 20mg) during the current episode
* current treatment with psychotherapy, antidepressants, antipsychotics, or mood stabilizers
* having contraindication to MRI scanning (such as metal in body) or unable to tolerate the scanning procedures (i.e., severe obesity, claustrophobia)
* acute, severe, or unstable medical or neurological illness
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
60 Years
Maximum Age:
90 Years
Study:
NCT01931202
Study Brief:
Protocol Section:
NCT01931202