Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 3:45 AM
Ignite Modification Date:
2025-12-25 @ 3:45 AM
NCT ID:
NCT00873002
Eligibility Criteria:
DISEASE CHARACTERISTICS:
* Histologically or cytologically confirmed hepatocellular carcinoma
* Metastatic and/or unresectable disease
* Child-Pugh score A or B
PATIENT CHARACTERISTICS:
* ECOG performance status 0-2
* Neutrophil count \> 1500/mm³
* Platelet count \> 100,000/mm³
* Hemoglobin ≥ 9 g/dL
* AST and ALT ≤ 2.5 times upper limit of normal (ULN) (≤ 5.0 times ULN if elevation due to disease involvement)
* Serum bilirubin ≤ 1.5 times ULN
* Serum creatinine ≤ 1.5 times ULN or creatinine clearance ≥ 50 mL/min
* Total serum calcium (corrected for serum albumin) or ionized calcium ≥ lower limit of normal (LLN)
* Serum potassium ≥ LLN
* Serum sodium ≥ LLN
* Serum albumin ≥ LLN or 3 g/dL
* LVEF ≥ LLN as demonstrated by baseline MUGA or ECHO
* TSH and free T4 within normal limits (thyroid hormone replacement therapy allowed)
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective double-method contraception (one being a barrier method) during and for 3 months after completion of study treatment
* INR \< 1.5 or PT/PTT within normal limits
* No impaired cardiac function including any 1 of the following:
* QTc \> 450 msec on screening ECG
* Congenital long QT syndrome
* History of sustained ventricular tachycardia
* History of ventricular fibrillation or torsades de pointes
* Bradycardia, defined as heart rate \< 50 beats per minute
* Patients with a pacemaker and heart rate ≥ 50 beats per minute are eligible
* Myocardial infarction or unstable angina within the past 6 months
* Congestive heart failure (NYHA class III-IV)
* Right bundle branch block and left anterior hemiblock (bifascicular block)
* No uncontrolled hypertension
* No thrombolic or embolic events (e.g., cerebrovascular accident and transient ischemic attacks) within the past 6 months
* No pulmonary hemorrhage/bleeding event \> CTCAE Grade 2 within the past 4 weeks
* No other hemorrhage/bleeding event \> CTCAE Grade 3 within the past 4 weeks
* No unresolved diarrhea \> CTCAE grade 1
* No other concurrent severe and/or uncontrolled medical conditions
* No other primary malignancy within the past 5 years except curatively treated carcinoma in situ of the cervix or basal cell or squamous cell carcinoma of the skin
* No serious non-healing wound, ulcer, or bone fracture
* No evidence or history of bleeding diathesis or coagulopathy
* No significant traumatic injury within the past 4 weeks
* No known or suspected allergy to sorafenib tosylate or any other study drug
* No condition that would impair a patient's ability to swallow whole pills
* No malabsorption problem
* No known human immunodeficiency virus (HIV) or hepatitis C positivity (baseline testing for HIV and hepatitis C is not required)
* No significant history of non-compliance to medical regimens
PRIOR CONCURRENT THERAPY:
* No prior HDAC inhibitors, DAC inhibitors, HSP90 inhibitors, sorafenib tosylate, or valproic acid for the treatment of cancer
* More than 4 weeks since prior chemotherapy, investigational drugs, or major surgery and recovered
* More than 4 weeks since open biopsy
* More than 5 days since prior and no concurrent valproic acid for any medical condition
* No concurrent St. John's wort or rifampin
* No concurrent drugs with a risk of causing torsades de pointes
* No concurrent CYP3A4 inhibitors
* No concurrent radiotherapy
* No concurrent grapefruit, grapefruit juice, or Seville (sour) oranges
* No other concurrent investigational therapy
* No other concurrent anticancer agents
* Concurrent anticoagulation treatment with warfarin or heparin allowed
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT00873002
Study Brief:
Protocol Section:
NCT00873002