Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 3:39 AM
Ignite Modification Date:
2025-12-25 @ 3:39 AM
NCT ID:
NCT00276302
Eligibility Criteria:
Inclusion Criteria:
* Pathologically confirmed diagnosis of GIST or STS
* Failed prior therapies
* ECOG performance status of 0-2
* Ability to adhere to the study visit schedule and all protocol requirements
Exclusion Criteria:
* Previous treatment with 17-AAG, DMAG, or other known Hsp90 inhibitor
* Participation in any investigational drug study or treatment with any other kinase inhibitor therapy within 2 weeks preceding start of treatment
* Concurrent radiation therapy is not permitted
* Concurrent treatment with any agent that alters CYP3A activity
* Concurrent treatment with any agent that may prolong the QTc interval
* Myocardial infarction or active ischemic heart disease within 6 months
* History of arrhythmia
* Baseline QTc \>450
* Grade 3 or greater peripheral neuropathy
* Renal insufficiency, serum creatinine \>1.5 x ULN
* Platelets \< 100,000 mm3
* AST and / or ALT \> 2.5 x ULN
* ANC \<1,500 cells/mm3
* Alkaline phosphatase \> 2.5 x ULN
* Amylase and lipase \> 1.5 x ULN
* Hemoglobin \< 9.0 g/dL
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT00276302
Study Brief:
Protocol Section:
NCT00276302