Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 3:37 AM
Ignite Modification Date:
2025-12-25 @ 3:37 AM
NCT ID:
NCT03504202
Eligibility Criteria:
Inclusion Criteria:
* ageā„18 years
* Typical angina symptoms
* Coronary angiography or coronary computed tomography examination showed no significant epicardial coronary artery stenosis (\<20%)
* Never used trimetazidine
* The CFR measured by the pressure guide wire is less than 2.0
* agree to participant the study and sign informed written consent
* available for six months follow up
Exclusion Criteria:
* Severe liver and kidney disease
* Contraindications of Trimetazidine
* Use of CYP3A inhibitors, such as diltiazem, verapamil, and other drugs that may affect CFR measurements
* QT interval extension
* Atrial fibrillation or left bundle branch block
* Left ventricular systolic dysfunction (EF \<55%)
* Coronary artery fistula
* Myocardial bridge
* Non-cardiogenic chest pain and other heart diseases
* Severe heart valve disease
* Diabetes
* Recent ACS( Acute coronary syndrome)
* Pregnancy
* Failed to complete inspection
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT03504202
Study Brief:
Protocol Section:
NCT03504202