Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 2:38 PM
Ignite Modification Date:
2025-12-24 @ 2:38 PM
NCT ID:
NCT07099859
Eligibility Criteria:
Inclusion criteria:
* Age ≥ 18 years;
* Postoperative period of aortic valve replacement surgery due to severe aortic regurgitation of any etiology;
* Signed Informed Consent Form.
Exclusion Criteria:
To avoid potential bias in data interpretation, the following patients will be excluded:
* Those who underwent cardiac surgery in the context of cardiogenic shock or infective endocarditis;
* Patients with ischemic cardiomyopathy;
* Patients with other significant concomitant valvular diseases.
Patients with conditions where losartan use may be harmful will also be excluded, including:
* Chronic kidney disease with an estimated glomerular filtration rate (eGFR \< 30 ml/min/1.73 m²);
* Systolic blood pressure (SBP) \< 90 mmHg at the time of randomization;
* Elevated serum potassium (K \> 5.5 mEq/L) at the time of randomization;
* Pregnancy;
* Known intolerance or allergy to losartan.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
85 Years
Study:
NCT07099859
Study Brief:
Protocol Section:
NCT07099859