Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 3:08 AM
Ignite Modification Date:
2025-12-25 @ 3:08 AM
NCT ID:
NCT02240433
Eligibility Criteria:
Inclusion Criteria:
* Have histological evidence of a diagnosis of HCC (except HCC with fibrolamellar or mixed histology) not amenable to curative surgery.
* Have Child-Pugh Class A.
* Have the presence of measurable or evaluable lesion as defined by the Response Evaluation Criteria In Solid Tumors (RECIST) v1.1. A measurable or evaluable lesion showing demonstrable progression after locoregional therapy could be also included.
* Have not received sorafenib prior to enrollment.
* Have resolution to Grade less than or equal 1 by the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 4.03 of all clinically significant toxic effects of prior locoregional therapy, surgery, chemoembolization, systemic chemotherapy.
* Have a performance status of less than or equal 1 on the Eastern Cooperative Oncology Group (ECOG) scale.
Exclusion Criteria:
* Are currently enrolled, or discontinued within 28 days prior to enrollment from, a clinical trial involving an investigational product or nonapproved use of a drug or device (other than the investigational product used in this study), or concurrently enrolled in any other type of medical research judged not to be scientifically or medically compatible with this study.
* Have undergone major surgery within 28 days prior to enrollment.
* Have undergone hepatic locoregional therapy (including radiation, surgery, hepatic arterial embolization, chemoembolization, radiofrequency ablation, cryoablation, percutaneous ethanol injection, or percutaneous microwave coagulation therapy) within 28 days prior to enrollment.
* Have moderate or severe cardiac disease.
* Myocardial infarction within 6 months prior to enrollment, unstable angina pectoris, New York Heart Association (NYHA) Class III/IV congestive heart failure, or uncontrolled hypertension.
* Documented major electrocardiogram (ECG) abnormalities at the investigator's discretion within 28 days prior to enrollment.
* Major abnormalities documented by echocardiography with Doppler at investigator's direction within 28 days prior to enrollment.
* Have persistently elevated brain natriuretic peptide (BNP) or elevated troponin I within 14 days prior to enrollment.
* Predisposing conditions that are consistent with development of aneurysms of the ascending aorta or aortic stress.
* Have a history of cardiac or aortic surgery.
* Have undergone liver transplant.
* Are pregnant or breastfeeding.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
20 Years
Study:
NCT02240433
Study Brief:
Protocol Section:
NCT02240433