Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 2:59 AM
Ignite Modification Date:
2025-12-25 @ 2:59 AM
NCT ID:
NCT05871333
Eligibility Criteria:
Inclusion Criteria:
1. Male or female patients aged 18 years old or more.
2. Patients diagnosed with gastrointestinal cancer eligible for chemotherapy
3. Eastern Cooperative Oncology Group (ECOG) performance ≤ 2.
4. Platelet count more than 100 × 10\^9/L.
5. Absolute neutrophil count: greater than 1.5 × 10\^9/L.
6. Aspartate aminotransferase level up to 2.5 times the upper limit normal.
7. Serum bilirubin level not more than 1.5 times the institutional upper limit normal.
8. Serum creatinine levels up to 1.5 mg% and 1.4 mg% for males and females respectively.
Exclusion Criteria:
1. Currently taking an angiotensin converting enzyme inhibitor (ACEi) or Angiotensin receptor blocker (ARB)
2. Prior reaction or intolerance to an ARB or ACE inhibitor, including but not limited to angioedema.
3. Pregnant or breastfeeding women.
4. Females in child bearing age not currently taking a protocol allowed version of contraception: intrauterine device, Depo-formulation of hormonal contraception.
5. Patient reported history or electronic medical record history of kidney disease, defined as:
Any history of dialysis. History of chronic kidney disease stage IV. Estimated Glomerular Filtration Rate (eGFR) of \< 30ml/min/1.73 m2 Other Kidney disease that in the opinion of investigator, would affect Losartan Clearance.
6. Patient reported dehydration and significantly decreased urine output in the past 72 hours.
7. Most recent systolic blood pressure prior to enrollment \<110 mmHg.
8. Current participation in any other clinical investigation.
9. Currently taking any drug contraindicated with Losartan administration.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT05871333
Study Brief:
Protocol Section:
NCT05871333