Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 2:50 AM
Ignite Modification Date:
2025-12-25 @ 2:50 AM
NCT ID:
NCT02757833
Eligibility Criteria:
Inclusion Criteria:
Late-life depression population inclusion criteria
* Patients in the LLD study arm will be females 60-85 years of age with a general good bill of health
* Patients in the LLD study arm will be presenting with mild to moderate MDD. Diagnosis of MDD will be confirmed through a Structured Clinical Interview for DSM-5-TR (SCID) Axis I disorder.
* LLD patients will have a Hamilton Depression Rating Scale (17-item version) score between 8-22
* LLD patients if being treated with any antidepressant agent, will be at a minimum of 4 weeks at therapeutic dosage of medication.
Healthy control (HC) population inclusion criteria:
* HC participants will be females between 60-85 years of age and in good general health
* HC participants will have no history of depression.
Exclusion Criteria:
* A primary diagnosis of any other mental health disorder (including substance dependence, post traumatic stress disorder, obsessive compulsive disorder, bipolar disorder, neurocognitive disorders, personality disorder, etc.)
* High risk of suicide as elicited by clinical interview
* History of head trauma
* History of severe vascular disease or cerebrovascular infarcts
* Any history of neurological disease (including Parkinson's disease or seizures)
* An ongoing acute episode of systemic inflammatory disease (e.g. rheumatoid arthritis, ulcerative colitis, crohn's disease)
* Any contraindications to MRI
* Additionally for Healthy Control participants only, a diagnosis of any mental health disorder
Healthy Volunteers:
True
Sex:
FEMALE
Minimum Age:
60 Years
Maximum Age:
85 Years
Study:
NCT02757833
Study Brief:
Protocol Section:
NCT02757833