Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 2:43 AM
Ignite Modification Date:
2025-12-25 @ 2:43 AM
NCT ID:
NCT00729833
Eligibility Criteria:
Inclusion Criteria:
* Histologically or cytologically confirmed advanced solid tumors relapsed or refractory to standard therapy or for whom no standard therapy exists.
* ECOG Performance Status of 0 or 1;
* Total IGF-1 level ≥100 ng/ml;
* ECOG Performance Status of 0 or 1
* Adequate bone marrow, renal, and hepatic function
Exclusion Criteria:
* Concurrent treatment with any antitumor agents with the exception of LHRH agnosits for prostate cancer patients
* Treatment with any other investigational therapy within 4 weeks prior to study treatment
* Major surgery within 4 weeks of study treatment
* Prior treatment that may increase the risk of cardiac complications
* Ongoing cardiac dysrhythmias of NCI CTCAE Grade 2 or greater
* Significant active cardiac disease, including hypertension that cannot be controlled by medications
* Greater than three (3) prior lines of cytotoxic therapy;
* Active infection
* Prior IGF-IR targeted therapy;
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT00729833
Study Brief:
Protocol Section:
NCT00729833