Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 2:43 AM
Ignite Modification Date:
2025-12-25 @ 2:43 AM
NCT ID:
NCT04633733
Eligibility Criteria:
Inclusion Criteria:
* Healthy male, 19 years ≤ age ≤ 45
* Body weight ≥ 50kg and 18.5 ≤ BMI ≤ 29.9kg/m2
* Subjects are agree to use contraceptives that protocol suggest and not provide sperm for up to 2 months after the last administration of the investigational drug
* Volunteer
Exclusion Criteria:
* Subject with serious cardiovascular, respiratory, hepatology, renal, hematologic, gastrointestinal, immunologic, dermal, neurologic, or psychological disease or history of such disease
* Subject with symptoms of acute disease within 28 days prior to investigational products dosing
* Subject with medical history which able to affect absorption, distribution, metabolism and excretion of drug
* Subject with hypersensitive reaction to following drug or history of clinically significant hypersensitive reaction to following drug
* Calcineurin inhibitor or Macrolides
* HL237
* Subject with clinically significant active chronic disease
* Subject with genetic deficiency such as galactose intolerance, Lapp lactose deficiency or glucosegalactose malabsorption
* Subjects who showed one or more of the following in a screening test including a retest
* AST, ALT \> UNL (upper normal limit) x 2.5
* Creatinine clearance =\< 80mL/min (Cockcroft-Gault GFR = (140-age) \* (Wt in kg) / (72 \* Cr))
* Results of ECG, QTc \> 450 msec
* Positive test results for hepatitis B virus surface antigen, anti-hepatitis C virus antibody, anti-Human Immunodeficiency virus antibody or venereal disease research laboratory test
* Use of any prescription medication within 14 days prior to study medication dosing
* Use of any over-the-counter(OTC) medication within 7 days prior to study medication dosing
* Subject with clinically significant allergic disease (except for mild allergic rhinitis and mild allergic dermatitis that are not needed to administer drug)
* Subject who is not able to taking standard meals provided by the institution
* Subject with whole blood donation within 60 days, component blood donation within 20 days
* Subjects receiving blood transfusion within 30 days prior to study medication dosing
* Participation in any clinical investigation within 6 months prior to study medication dosing
* Use of any medication effected on drug enzyme induction or inhibition such as barbitals within 30 days prior to study medication dosing
* Subjects who have continuously consumed grapefruit juice or caffeine (grapefruit juice or caffeine \> 5 cups/day), or who can't refrain from intake during hospitalization
* Subjects who have continued to drink alcohol (alcohol\> 30 g/day) or who can't quit drinking during hospitalization
* Severe heavy smoker(cigarette \> 10 cigarettes per day) or subjects who can't quit smoking during hospitalization
* Subjects that the investigator deems unsuitable for participation in the clinical trial due to laboratory test results or other excuse such as non-responding to request or instruction by investigator
Healthy Volunteers:
True
Sex:
MALE
Minimum Age:
19 Years
Maximum Age:
45 Years
Study:
NCT04633733
Study Brief:
Protocol Section:
NCT04633733