Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 2:42 AM
Ignite Modification Date:
2025-12-25 @ 2:42 AM
NCT ID:
NCT02205333
Eligibility Criteria:
Inclusion Criteria:
* Adults \>/= 18 years old
* Histologically or cytologically confirmed advanced solid tumors that are refractory to standard therapy or for which no standard therapy exists (Monotherapy and in Cohorts A and B)
* At least one lesion measurable by RECIST not previously irradiated (Monotherapy and in Cohorts A and B)
* Histologically confirmed DLBCL(Cohort C)
* Adequate organ and marrow function
* ECOG performance status of 0 or 1
* Willingness to provide consent for biopsy samples
Exclusion Criteria:
* Prior exposure to immunotherapy (either as a single agent or in combination) including but not limited to CD137 or OX40 agonists, anti-CTLA-4, anti-PD-1, or anti-PD-L1, anti-PD-L2 antibody or pathway-targeting agents
* History of organ transplant that requires use of immunosuppressives
* History of primary immunodeficiency or tuberculosis
* Active or prior documented autoimmune disease within the past 3 years
* Active or chronic viral hepatitis or history of any type of hepatitis within the last 6 months
* Major surgical procedure within 30 days prior to the first dose of investigational product or still recovering from prior surgery
* Women who are pregnant or lactating
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
99 Years
Study:
NCT02205333
Study Brief:
Protocol Section:
NCT02205333