Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 2:39 AM
Ignite Modification Date:
2025-12-25 @ 2:39 AM
NCT ID:
NCT06816134
Eligibility Criteria:
Inclusion Criteria:
* Confirmed diagnosis of AML or ALL according to WHO 2022 guideline criteria, with indications for allo-HSCT list below:
1. Relapsed/primary refractory (definitions refer to NCCN 2025) or genetic high-risk group AML at diagnosis (risk stratification refers to ELN 2022)
2. High-risk at diagnosis (risk stratification refers to ELN 2022) or MRD positive before transplantation B-ALL
3. Confirmed diagnosis of T-ALL
4. History of central nervous system leukemia (CNSL) or histopathologically confirmed extramedullary manifestation (EMD) during the course of the AML or ALL
* Age 15-65 years old (≤ 65 years old)
* HCT-CI score \< 2 points ECOG 0-2 points
* Adequate organ function:
1. Cardiac NYHA grade ≤ 2, left ventricular ejection fraction ≥55%
2. Creatinine clearance ≥ 50ml/min
3. ALT and AST ≤ 2.5 times the upper limit of the normal range, and total bilirubin ≤ 1.5 times the upper limit of the normal range
4. Oxygen saturation \> 92% without oxygen
* Expected survival time ≥ 3 months
* Ability to understand and voluntarily sign the informed consent form
Exclusion Criteria:
* With other malignant tumors and have received any treatment for this tumor within the past 3 years
* Previous or current other CNS disease (such as epilepsy, generalized seizure disorder, paresis, aphasia, stroke, severe brain injuries, dementia, Parkinson's disease, cerebellar disease, organic brain syndrome, or psychosis) or any CNS-related autoimmune disease
* HIV/Syphilis infection or uncontrolled active other infections (bacteria or fungus or virus is included)
* With active hepatitis B or hepatitis C infection
* Patients received cardiac angioplasty or stent implantation within 12 months before signing the informed consent form, or have symptoms requiring medical treatment for coronary heart disease
* With primary immunodeficiency or active autoimmune disease
* Previous history of severe immediate hypersensitivity reactions to any of the drugs to be used in this study
* Received a live vaccine within 6 weeks prior to screening
* Pregnant, lactating females and patients of childbearing potential who are unwilling to use contraception
* Inability to cooperate with the requirements of study, treatment and monitoring due to psychiatric illness or other conditions
* Patients not suitable for the study according to the investigator's assessment
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
15 Years
Maximum Age:
65 Years
Study:
NCT06816134
Study Brief:
Protocol Section:
NCT06816134