Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 2:28 PM
Ignite Modification Date:
2025-12-24 @ 2:28 PM
NCT ID:
NCT03215459
Eligibility Criteria:
Inclusion Criteria:
* Histologically proven pancreatic cancer
* Due to commence palliative chemotherapy (including as part of a Clinical Trial of an Investigational Medicinal Product (CTIMP)).
* Able to undertake CPET
* Expected life expectancy \>3 months
* Age 18+
Exclusion Criteria:
• Haemoglobin \<10g/L
Absolute contraindications for cardiopulmonary exercise testing:
* Acute myocardial infarction (3-5 days)
* Unstable angina
* Uncontrolled arrhythmias causing symptoms or hemodynamic comprise
* Syncope
* Active endocarditis
* Acute myocarditis or pericarditis
* Symptomatic severe aortic stenosis
* Uncontrolled heart failure
* Acute pulmonary embolus or pulmonary infarction
* Thrombosis of lower extremities
* Suspected dissecting aneurysm
* Uncontrolled asthma
* Pulmonary edema
* Room air desaturation at rest ≤85%
* Respiratory failure
* Acute noncardiopulmonary disorder that may aggravated by exercise (i.e. renal failure, thyrotoxicosis)
* Mental impairment leading to inability to cooperate
Relative contraindications for cardiopulmonary exercise testing:
* Left main coronary stenosis or its equivalent
* Moderate stenotic valvular heart disease
* Severe untreated arterial hypertension at rest (\>200mm Hg systolic, \> 120mm Hg diastolic)
* Tachyarrhythmias or bradyarrhythmias
* High-degree atrioventricular block
* Hypertrophic cardiomyopathy
* Significant pulmonary hypertension
* Advanced or complicated pregnancy
* Orthopaedic impairment that compromises
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT03215459
Study Brief:
Protocol Section:
NCT03215459