Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 2:36 AM
Ignite Modification Date:
2025-12-25 @ 2:36 AM
NCT ID:
NCT04663334
Eligibility Criteria:
Inclusion Criteria:
* Adults older than 18 years. For female of childbearing age, active contraceptive method is recommended.
* patients with severe symptomatic aortic stenosis secondary to degenerative disease confirmed by transthoracic echocardiography (mean gradient \>40 mmHg and/or valve area \<1 cm2) and with significant coronary artery disease (epicardial coronary stenosis angiography \> or = to 50%)
Exclusion Criteria:
* Severe CAD with tritroncular lesions or severe stenosis (\>90 %) of left main artery or proximal left anterior descending artery
* Lack of viability in myocardial territory of interest
* History of bypass coronary surgery or heart transplantation
* Severe left ventricular systolic dysfunction, characterized by an ejection fraction \< 35 %
* Severe renal impairment (Creatinine clearance \<30 ml/min/1.73 m2)
* Absolute contraindication to intravenous adenosin
* Pregnant or nursing women Patients under guardianship, curatorship, or protection of justice
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT04663334
Study Brief:
Protocol Section:
NCT04663334