Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 2:34 AM
Ignite Modification Date:
2025-12-25 @ 2:34 AM
NCT ID:
NCT05373134
Eligibility Criteria:
Inclusion Criteria:
* Age 18 - 70 years
* Evidence of portal hypertension
* Intrapulmonary vascular dilatation in the form of shunting diagnosed on contrast echocardiogram
* AaPO2 \> 15mmHg on seated room air (ABG) if age \<65years and \>20mmHg if Age≥ 70 years
Exclusion Criteria:
* Child C cirrhosis with CTP \> 10 or with refractory ascites
* Intrinsic significant cardiopulmonary disease
1. PFT indicating severe obstructive ventilatory defect (FEV1/FVC \< 70)
2. Hepatic hydrothorax, Portopulmonary hypertension
3. Moderate and severe left ventricular systolic dysfunction
4. Inability to perform Pulmonary function test
5. Intracardiac shunting
* Current use of exogenous nitrates
* Patients already on pentoxifylline
* Prior intolerance to pentoxifylline
* Very severe cases of HPS (A-aO2 gradient ≥ 15mm Hg, PO2 \<50 mmHg)
* Active bacterial infections, active hepatic encephalopathy
* Known malignancy including HCC
* SBP on secondary prophylaxis
* CKD with creatinine clearance \< 30
* Enrolled in other trials
* Has a liver transplant option
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
70 Years
Study:
NCT05373134
Study Brief:
Protocol Section:
NCT05373134