Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 2:30 AM
Ignite Modification Date:
2025-12-25 @ 2:30 AM
NCT ID:
NCT01881334
Eligibility Criteria:
Inclusion Criteria:
* Have a consenting related haplo-identical (3/6, 4/6, or 5/6 if DRB1 mismatch) stem cell donor.
* Have one or two available 4, 5, or 6/6 antigen matching unrelated UCB unit(s) that will deliver a total cell dose \>3.0 x 10e7 cells/kg. Patients who do not have a single UCB unit that will deliver the minimum required cell dose, two partially HLA-matched UCB units which together meet the minimum cell dose requirement, can be used for 1 transplant. These units must be HLA-matched minimally at 4 of 6 HLA-A and B (at intermediate resolution by molecular typing) and DRB1 (at high resolution by molecular typing) loci with the patient, and HLA-matched at 3 of 6 HLA- A, B, DRB1 loci with each other (using same resolution of HLA typing as indicated above). There is no limitation on maximum cell dose.
* Have a high risk or refractory malignancy, or non-malignant disorder amenable to stem cell transplantation therapy.
* Meet eligibility requirements for allogeneic transplant per institutional standard practices.
* Have given written informed consent according to FDA guidelines (or consent of parent/legal guardian as applicable).
* Be \<65 years of age at the time of study enrollment.
Exclusion Criteria:
* Have a consenting 8/8 or 10/10 allele matched, consenting, related or unrelated hematopoietic stem cell transplant (HSCT) donor.
* Have a life expectancy of less than 3 months.
* Have uncontrolled infections at time of cytoreduction.
Sex:
ALL
Maximum Age:
65 Years
Study:
NCT01881334
Study Brief:
Protocol Section:
NCT01881334