Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 2:28 AM
Ignite Modification Date:
2025-12-25 @ 2:28 AM
NCT ID:
NCT01157234
Eligibility Criteria:
Inclusion Criteria:
* Men or women at least 18 years of age who are recipients of - a solitary kidney or combined kidney-pancreas transplant within the last twenty four months
* Current diagnosis of hypertension
* Normal hepatic enzymes
* Estimated creatinine clearance (by cockcroft-gault formula) \>or= 30 ml/min
Exclusion Criteria:
* Any contraindication to taking beta-blockers, specifically Nebivolol or Metoprolol. Conditions such as : (bradycardia heart rate (HR) \<60 beats per minute , heart block \> 1st degree, decompensated cardiac failure, sick sinus syndrome (unless permanent pacemaker in place), severe hepatic impairment( defined as elevation of aspartamine aminotransferase , alanine aminotransferase, or bilirubin levels to three times upper limit of normal reference range), severe peripheral arterial circulatory disorder, history of bronchospasm and /or asthma and /or regular medication with inhaled bronchodilators. or , or any medical condition that in the opinion of the investigator may interfere with the subject's ability to successfully complete the protocol.
* Any medical condition which, in the opinion of the Principal Investigator, might compromise the safety of the subject in participating in the protocol such as hypotension or not requiring antihypertensive medications.
* Any serious systemic disease that might complicate management and reduce life expectancy.
* Uncontrolled hypertension defined as systolic blood pressure (SBP) \> 210 or diastolic blood pressure (DBP) \> 120 mm Hg.
* Symptomatic hypotension
* Previous intolerance to beta blockers
* Cerebrovascular accident within 3 months of randomization
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT01157234
Study Brief:
Protocol Section:
NCT01157234