Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 2:20 AM
Ignite Modification Date:
2025-12-25 @ 2:20 AM
NCT ID:
NCT03295734
Eligibility Criteria:
Inclusion Criteria:
* Age 60 years and older
* Hypertension - untreated (SBP ≥ 140 mm Hg or DBP ≥ 90 mm Hg) or treated
* \> 290 seconds needed to complete long-distance corridor walk test
* Sedentary lifestyle, defined as \<150 min/wk of moderate physical activity
* Willingness to participate in all study procedures, including allowing study team to communicate with primary care physician regarding changes in antihypertensive treatment
Exclusion Criteria:
* BP \> 140/90, despite the use of three or more anti-hypertensive drugs
* SBP \> 180 mm Hg or DBP \> 110 mm Hg
* Chronic kidney disease
* Serum creatinine \>2.5 mg/dL in men or \>2.0 mg/dL in women
* Serum potassium outside normal reference range
* Urinary protein \> 1 on dipstick
* Abnormal liver enzymes (AST, ALT, or alkaline phosphatase \> 2.5 times the upper limit of normal)
* Severe cardiac disease, including NYHA Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina
* Acute myocardial infarction identified by ECG
* Significant cognitive impairment, defined as a known diagnosis of dementia or a Mini-Mental State Examination exam score \< 24;
* Simultaneous participation in another intervention trial
* Known hypersensitivity to ACE inhibitors (exclusion only to perindopril arm; will be randomized among other two interventions)
* Any other condition that would preclude participating based upon judgement of PI or study clinician team
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
60 Years
Study:
NCT03295734
Study Brief:
Protocol Section:
NCT03295734