Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 2:22 PM
Ignite Modification Date:
2025-12-24 @ 2:22 PM
NCT ID:
NCT05127395
Eligibility Criteria:
Inclusion Criteria:
* Patients Admitted to a SSM Health - St. Clare (STL), St. Mary's (STL), Saint Louis University Hospital (STL), St. Anthony's (OKC), St. Mary's Madison (WIS), Rush University Medical Center (RUMC), or Methodist Dallas Medical Center
* \> 18 years old
* Positive cerebrospinal fluid (CSF) PCR for HSV-1 or HSV-2
* BMI \> 30 kg/m2
* Received guideline-approved, weight-based doses of IV acyclovir for HSV encephalitis for at least 72 hours during the index admission
* Received appropriately renal dose-adjusted doses of IV acyclovir per package insert recommendations
Exclusion Criteria:
* More than one dosing weight strategy utilized for \> 24 hours for IV acyclovir dosing during the index admission
* Patients transferred to the hospital already on IV acyclovir for HSV encephalitis
* ESRD on admission
* Concomitant pathogen causing meningitis or encephalitis
* Oral acyclovir used for treatment
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT05127395
Study Brief:
Protocol Section:
NCT05127395