Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-24 @ 2:21 PM
Ignite Modification Date:
2025-12-24 @ 2:21 PM
NCT ID:
NCT05072795
Eligibility Criteria:
Inclusion Criteria:
* Age 50-80.
* Women must be \>1 year post-menopausal.
* English as a first/primary language.
* Functional visual and auditory acuity (aided or unaided) to complete tests.
* Capacity to independently provide informed consent and function at an intellectual level sufficient to allow completion of all instruments.
* Currently meets DSM-5 criteria for CUD or uses cannabis at least 4 days per week
* Consent to abstain from alcohol and cannabis use for \>12 hours prior to Study Visit (Day 0), and TSST (Day 8).
* Consent to abstain from all drugs other than cannabis or nicotine for the duration of the study.
Exclusion Criteria:
* Meet DSM-5 criteria for moderate or severe alcohol or substance use disorder (other than nicotine or cannabis) within the last 12 months.
* History of major neurocognitive disorder or developmental disorder per DSM-5.
* A Telephone Interview for Cognitive Status (TICS) score of less than or equal to 22.
* Significant or unstable medical condition/s that impact cognition as deemed by study investigators, such as active significant cardiac, cerebrovascular, neoplastic, infectious, or metabolic disease, or longstanding and intractable severe mental illness (e.g. schizophrenia spectrum disorder, bipolar disorder).
* Daily use of medications that adversely impact cognition in aging (i.e. anticholinergics and sedatives).
* Current suicidal or homicidal ideation/risk.
* Unable to complete/comply with procedures or pose threat to research staff.
* Standard MRI contraindications (e.g., implants, claustrophobia).
* Women who are pregnant, nursing, or of childbearing potential and not practicing and effective means of birth control.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
50 Years
Maximum Age:
80 Years
Study:
NCT05072795
Study Brief:
Protocol Section:
NCT05072795