Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 2:11 AM
Ignite Modification Date:
2025-12-25 @ 2:11 AM
NCT ID:
NCT04974060
Eligibility Criteria:
Inclusion Criteria:
* Age ≥ 18 years
* Severe TBI (3 \< glasgow coma scale (GCS) ≤ 8)
* Hyperventilation (PaCO2 \< 35 mmHg and pondus hydrogenii (pH) \> 7.45)
* Presence of an endotracheal tube
* Assisted ventilation mode (CPAP/PSV)
Exclusion Criteria:
* Induced/iatrogenic hyperventilation
* No informed consent was signed
* Transcranial doppler sonography (TCD) data collection cannot be completed due to anatomical structure
* Severe multiple organ failure, persistent high fever, massive thoraco-peritoneal effusion
* Medical history of major craniocerebral injury and chronic obstructive pulmonary disease (COPD)
* Conformed or Suspected history of opioid-related adverse reactions
* Withdraw from the study due to the change of patient's condition and other methods of treatment and intervention are needed
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT04974060
Study Brief:
Protocol Section:
NCT04974060