Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 2:04 AM
Ignite Modification Date:
2025-12-25 @ 2:04 AM
NCT ID:
NCT02255760
Eligibility Criteria:
Inclusion Criteria:
1. Age 18 through 60 years at the time of screening
2. Written informed consent
3. Weight greater than or equal to (\>=) 45 kilogram (kg) and less than or equal to (\<=) 110 kg at screening
4. Healthy by medical history, physical examination, and baseline safety laboratory studies
5. Systolic blood pressure (BP) less than (\<) 140 millimeter of mercury (mmHg) and diastolic BP \< 90 mmHg at screening
6. Electrocardiogram (ECG) without clinically significant abnormalities at screening
7. Able to complete the follow-up period through Day 61 as required by the protocol.
8. Females of childbearing potential who are sexually active with a nonsterilized male partner must have used a highly effective method of contraception for at least 28 days prior to dosing with investigational product and must agree to continue using such precautions through Day 61 of the study.
Exclusion Criteria:
1. Acute (time-limited) illness, including fever 99.5 degree Fahrenheit (0\^F), on day prior to or day of planned dosing
2. Any drug therapy within 7 days prior to Day 1 (except contraceptives or a single use of acetaminophen, aspirin, antihistamine, or combination over-the-counter (OTC) product that contains acetaminophen with an antihistamine, or OTC non-steroidal anti inflammatory agent at a dose equal to or lower than that recommended on the package). Vitamins and other nutritional supplements that are not newly introduced, ie, have been taken for at least 30 days prior to enrolment, are not exclusionary
3. Blood drawn in excess of a total of 450 mL (1 unit) for any reason within 2 months prior to screening
4. Receipt of immunoglobulin or blood products within 6 months prior to screening
5. Receipt of any investigational product in the preceding 90 days or expected receipt of investigational product during the period of study follow-up, or concurrent participation in another interventional study Receipt of any vaccine within 7 days prior to investigational product dosing or planned receipt within 61 days after investigational product dosing except for influenza vaccine administered at least 28 days after dosing
6. Previous receipt of a mAb
7. Immunodeficiency due to illness, including human immunodeficiency virus (HIV) infection, or due to drugs, including any course of glucocorticoid therapy exceeding 2 weeks of prednisone or equivalent at a dose of 20 mg daily or every other day within 6 months prior to screening. HIV testing must be negative at screening
8. History of allergic disease or reactions likely to be exacerbated by any component of the investigational product
9. Either history of active infection with hepatitis B or C
10. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), or serum creatinine above the upper limit of normal (ULN) or hemoglobin, white blood cell count, or platelet count below the lower limit of normal at screening and in the predose blood sample
11. Pregnant or nursing mother
13\. History of alcohol or drug abuse within the past 2 years.
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
60 Years
Study:
NCT02255760
Study Brief:
Protocol Section:
NCT02255760