Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 2:02 AM
Ignite Modification Date:
2025-12-25 @ 2:02 AM
NCT ID:
NCT06682260
Eligibility Criteria:
Inclusion Criteria:
* Age ≥ 18 years
* Clinical diagnosis of AHF requiring hospitalization
* Systolic blood pressure ≥85 mmHg
* Echocardiographic signs of cardiac dysfunction, by at least one of
* Left ventricular ejection fraction ≤45%
* Abnormal left ventricular filling with dilatation of the left atrium
* Elevated filling pressures (systolic pulmonary artery pressure\>30, dilated vena cava inferior or E/é\>10)
* Significant left-sided heart valve disease
Exclusion Criteria:
* Ongoing ventricular taky- or brady-arrythmias or supraventricular arrhythmias with heart rate \> 180 or \< 40 bpm.
* Retinopathy or intraocular lens implantation (contraindication to Valsalva maneuver)
* Recent myocardial infarction or thromboembolic events.
* Intake of sildenafil or vardenafil withing 24 h and tadalafil within 48 h.
* Absolute contraindication for vasodilation using nitroglycerin as assessed by treating physician
* Intravenous administration of furosemide within 2 hours of baseline measurements
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT06682260
Study Brief:
Protocol Section:
NCT06682260