Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 1:40 AM
Ignite Modification Date:
2025-12-25 @ 1:40 AM
NCT ID:
NCT06028594
Eligibility Criteria:
Key Inclusion Criteria:
1. Patients who have completed either the end of treatment visit of the open-label treatment period or open-label extension period in one of the following parent studies:
* An Open-Label Extension Study to Evaluate the Long-Term Safety, Tolerability, and Efficacy of Pozelimab and Cemdisiran Combination Therapy in Patients with Paroxysmal Nocturnal Hemoglobinuria (R3918-PNH-2050 \[NCT05744921\])
* A Randomized, Open-Label, Two-Arm Study to Evaluate the Safety, Efficacy, and Pharmacodynamic Effects of Pozelimab and Cemdisiran Combination Treatment in Patients with Paroxysmal Nocturnal Hemoglobinuria Who Have Received Pozelimab Monotherapy (R3918-PNH-2092 \[NCT04811716\])
* A Single Arm, Open-Label Study to Assess the Safety, Efficacy, and Pharmacodynamic Effects of Pozelimab and Cemdisiran Combination Therapy in Patients with Paroxysmal Nocturnal Hemoglobinuria Who Switch from Eculizumab Therapy (R3918-PNH-20105 \[NCT04888507\]). Note: In some countries, patients that would normally enter into the R3918-PNH-2050 (NCT05744921) parent study before entering this expanded access program, may be given the opportunity to skip R3918-PNH-2050 (NCT05744921) and go straight into this expanded access program, with Regeneron's permission
2. Patients who have been enrolled in R3918-PNH-2022 (NCT05131204), with Regeneron's permission
3. Willing and able to comply with clinic visits and related standard-of-care procedures
4. With Regeneron's permission, patients who have been enrolled in other PNH studies as appropriate
Key Exclusion Criteria:
1. Significant history or concerns of non-compliance that could impact the patient's safety per the treating physician
2. Any new condition or worsening of an existing condition which, in the opinion of the treating physician, would make the patient unsuitable for enrollment or could interfere with the patient participating in or completing the program
NOTE: Other protocol defined inclusion / exclusion criteria apply
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT06028594
Study Brief:
Protocol Section:
NCT06028594