Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 1:38 AM
Ignite Modification Date:
2025-12-25 @ 1:38 AM
NCT ID:
NCT02423694
Eligibility Criteria:
Inclusion Criteria:
* Conforms to the diagnosis standard of STRAW-10 for perimenopause, conforms to the diagnosis standard of The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) for depression, and conforms to the diagnosis standard of The International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10) F32.0(mild depression) or F32.1(moderate depression);
* Fisrt attack during perimenopausal period;
* HAMD-17 score \>7 and \<23;
* Age ≥45 to ≤55;
* No hormone replacement therapy (HRT) or no antidepressant 3 months before into the group;
* Sign the consent consent, volunteered for this study
Exclusion Criteria:
* Fail to rule out the possibility of suicide in depression factor of The Symptom Checklist (SCL-90);
* Application of estrogen, progesterone, selective serotonin reuptake inhibitors (SSRIs), soybean isoflavone, vitamin E or black cohosh in recent 4 weeks;
* Allergic to citalopram or escitalopram tablets;
* Taken the non selective, irreversible inhibitor of monoamine oxidase (MAOIs) in recent 2 weeks;
* Taken linezolid, pimozide, tryptophane,tramadol, triptans or other drugs that may cause drug adverse reactions in recent 2 weeks;
* Patient with prolongation of the QT interval or congenital long QT syndrome
* Taken herbs or products that contain isatin, pilose antler, hawthorn, fleeceflower root, common St.John's wort herb, hypericin;
* Ovarian dropsy or hysteromyoma with more than 4cm diameter, oophorectomy, or hysterectomy;
* Mandatory indications of hormonotherapy, such as surgery-induced menopause or osteoporosis;
* Patient with history of radiotherapy or chemotherapy, or undergoing radiotherapy or chemotherapy;
* Vaginal bleeding of undetermined origin;
* Patient with coagulation disorders, or taking anticoagulants such as Warfarin, or heparin;
* Patient with skin diseases, such as eczema,or psoriasis;
* Serious hepatic insufficiency or serious renal inadequacy;
* Uncontrolled hypertension, diabetes, or thyroid disease;
* Diabetic neuropathy, or malignant tumor;
* Pregnancy intention, in pregnancy or lactation;
* Regular use of sedative and anti anxiety drugs;
* The long-term smoking and/or drinking;
* Having Pacemaker or artificial joint；
* Electrolyte is disorder, serious heart disease or other potential life-threatening disease patients;
* Compliance may be poor or fear of acupuncture.
Healthy Volunteers:
False
Sex:
FEMALE
Minimum Age:
45 Years
Maximum Age:
55 Years
Study:
NCT02423694
Study Brief:
Protocol Section:
NCT02423694