Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 1:33 AM
Ignite Modification Date:
2025-12-25 @ 1:33 AM
NCT ID:
NCT03779594
Eligibility Criteria:
Inclusion Criteria:
Included will be subjects with a probable diagnosis of NPH. The diagnosis will be based primarily on presence of gait impairment plus at least one other impairment in urinary symptoms, cognition impairment or both.
1. Are 50 years old or older.
2. Patients who meet the criteria for NPH based on:
* A typical personal history.
* A typical brain imaging on head CT or MRI.
* Normal lumbar puncture findings excluding other conditions.
* Exclusion of other more likely diagnosis.
3. Patients who underwent large-volume spinal tap and subsequently improved clinically by at least 10% in gait function or cognition.
Exclusion Criteria:
* Cirrhosis or marked liver disease or dysfunction.
* Severe renal disease or dysfunction.
* Acidosis.
* Hypersensitivity to acetazolamide, sulfonamides, or any component of the formulation.
* Decreased sodium and/or potassium levels.
* Adrenocortical insufficiency.
* Patients with cognitive impairment who will not be able to give informed consent.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
50 Years
Study:
NCT03779594
Study Brief:
Protocol Section:
NCT03779594