Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 1:25 AM
Ignite Modification Date:
2025-12-25 @ 1:25 AM
NCT ID:
NCT05008393
Eligibility Criteria:
Inclusion Criteria:
1. Adult patients (age ≥ 18 years);
2. COVID-19 diagnosis confirmed by:
1. Detection of SARS-CoV-2 by reverse transcription polymerase chain reaction (RT-PCR), or
2. Rapid genetic or antigen tests validated by Brazilian National Health Surveillance Agency (ANVISA);
3. Mild or moderate symptoms without indication for hospitalization;
4. Symptoms started seven days ago or less;
5. Be able to access the study's online questionnaire.
Exclusion Criteria:
1. Pregnant or lactating women;
2. Known allergy or hypersensitivity to the study drug;
3. Patients at high risk of bleeding, defined by:
1. Previous Intracranial hemorrhage,
2. Ischemic stroke in the last 3 months,
3. Anatomical vascular alteration of the central nervous system known, such as aneurysms or arteriovenous malformations,
4. Malignant neoplasm of the central nervous system known,
5. Metastatic solid neoplasia,
6. Significant closed head or facial trauma in the last 3 months (defined as any trauma that required medical evaluation or hospitalization),
7. Known intracranial abnormalities not listed as absolute contraindications (e.g., benign intracranial tumor),
8. Bleeding in the last 2 to 4 weeks (excluding menstrual bleeding),
9. Surgical procedure in the last 3 weeks,
10. Current use of full-dose anticoagulants (warfarin, enoxaparin or new anticoagulants) or dual antiplatelet therapy,
11. Thrombocytopenia (\<100,000/mL) or international normalized ratio (INR) \> 1.3;
4. Renal failure, defined as glomerular filtration rate (GFR) estimated by the formulas Modification of Diet in Renal Disease (MDRD) or Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) \<30 mL/min/1.73m2;
5. Previous participation in the study;
6. History of liver disease (cirrhosis) reported by the patient or in medical records, presence of esophageal varices or presence of ascites;
7. Decompensated heart failure, defined by the presence of dyspnea attributed to cardiac cause, edema of the lower limbs, crackles on pulmonary auscultation or pathological jugular turgency.
8. Participation in other clinical trials with antivirals in COVID-19
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT05008393
Study Brief:
Protocol Section:
NCT05008393