Description Module
The Description Module contains narrative descriptions of the clinical trial, including a brief summary and detailed description. These descriptions provide important information about the study's purpose, methodology, and key details in language accessible to both researchers and the general public.
Description Module path is as follows:
Study -> Protocol Section -> Description Module
Description Module
Ignite Creation Date:
2025-12-25 @ 12:10 AM
Ignite Modification Date:
2025-12-25 @ 12:10 AM
NCT ID:
NCT06724458
Brief Summary:
The number of repetitions able to be performed during resistance exercise is impacted by the load an individual is working against. Heavier loads lead to less repetitions being performed and lighter loads lead to more repetitions being performed. As the load gets progressively lighter, it is hypothesized that oxygen availability becomes an important factor for performance of maximum repetitions. Peripheral blood flow occlusion using exercise specific blood flow occlusion cuffs can allow for oxygen availability to be controlled by altering the amount of blood able to get to working muscles. To date, no study has examined the effect of varying exercise loads, from heavy to light, on maximum repetitions able to be performed with and without blood flow occlusion.
Detailed Description:
The study aims to assess the difference in maximum repetitions performed at varying percentages of participants maximum strength and the impact peripheral blood flow occlusion has on performance
The study will take three weeks to complete with a total of six visits. The entire time commitment will be seven hours. During week 1 participants will visit the lab twice to perform baseline assessments of strength, endurance, muscle size and will also receive a resting thighs muscle biopsy. During weeks 2 and 3 participants will visit the lab twice per week to complete three out of twelve randomized exercise interventions per visit. The interventions are maximum repetitions at 80/40/30/25/20/15% of knee-extension one-repetition maximum as well as 90/70/60/55/50/45% of barbell curl one-repetition maximum; all of the listed conditions will be tested in a free-flow and blood flow occluded state (i.e., 12 total exercise interventions for the knee extension and 12 total exercise interventions for the barbell curl).
Study:
NCT06724458
Study Brief:
Protocol Section:
NCT06724458