Description Module
The Description Module contains narrative descriptions of the clinical trial, including a brief summary and detailed description. These descriptions provide important information about the study's purpose, methodology, and key details in language accessible to both researchers and the general public.
Description Module path is as follows:
Study -> Protocol Section -> Description Module
Description Module
Ignite Creation Date:
2025-12-26 @ 11:11 PM
Ignite Modification Date:
2025-12-26 @ 11:11 PM
NCT ID:
NCT00577512
Brief Summary:
This study is being done in an attempt to improve the remission rate and the survival time for subjects with high-risk myeloma. It is hoped that by giving higher doses of commonly used chemotherapy drugs and by giving courses closer together (before the myeloma comes back or gets worse), subjects in this study will have better outcomes.
Detailed Description:
This study has the following goals:
* To find out how many subjects treated with high dose DTPACE (Dexamethasone, Thalidomide, CisPlatin, Adriamycin, Cyclophosphamide, and Etoposide. (HD DTPACE) on this protocol will have a complete response or near complete response that lasts for 6 months or longer.
* In subjects achieving a response, to find out how long the response will last.
* To learn more about the side effects of this treatment.
Up to 75 subjects, male or female, age 18 and older, regardless of race or ethnicity, will participate in this study at the University of Arkansas for Medical Sciences (UAMS) only.
The treatment in this study is divided into 3 parts
* High dose DTPACE and stem cell collection if you do not already have sufficient stem cells stored.
* High dose DTPACE and stem cell re-infusion.
* Velcade, Thalidomide, Dexamethasone (sometimes known as VTD) Maintenance therapy.
Study:
NCT00577512
Study Brief:
Protocol Section:
NCT00577512