Description Module
The Description Module contains narrative descriptions of the clinical trial, including a brief summary and detailed description. These descriptions provide important information about the study's purpose, methodology, and key details in language accessible to both researchers and the general public.
Description Module path is as follows:
Study -> Protocol Section -> Description Module
Description Module
Ignite Creation Date:
2025-12-26 @ 10:17 PM
Ignite Modification Date:
2025-12-26 @ 10:17 PM
NCT ID:
NCT05344612
Brief Summary:
Rationale:
Patients with chest pain usually undergo multiple diagnostic examinations to demonstrate or rule out atherosclerotic coronary artery disease (CAD). In addition to high healthcare costs, some of the examinations do not assess the presence of CAD, which means that patients may be undertreated and are at risk for myocardial infarction. A uniform diagnostic and treatment strategy that uses computed tomography coronary angiography (CTCA) as initial examination may reduce major adverse cardiac events (MACE) and may reduce healthcare costs. In addition, we hypothesize that this strategy improves angina-related health status and reduces the number of invasive coronary angiograms (CAG's).
Objectives:
* To show that the intervention is non-inferior to the control with regards to clinical outcomes
* To show superiority of the intervention with regards to clinical outcomes
Study design: National multicenter prospective randomized controlled trial.
Study population: Patients with suspected stable CAD.
Intervention: upfront CTCA to diagnose CAD and guide optimal medical therapy (OMT). Patients with obstructive CAD and refractory angina despite OMT will undergo non-invasive ischemia imaging to guide revascularization.
Control: Standard of care. Diagnosis and treatment are at the discretion of the attending cardiologist.
Main study end point: Composite of all-cause mortality and non-fatal myocardial infarction.
Study:
NCT05344612
Study Brief:
Protocol Section:
NCT05344612