Description Module
The Description Module contains narrative descriptions of the clinical trial, including a brief summary and detailed description. These descriptions provide important information about the study's purpose, methodology, and key details in language accessible to both researchers and the general public.
Description Module path is as follows:
Study -> Protocol Section -> Description Module
Description Module
Ignite Creation Date:
2025-12-24 @ 11:36 PM
Ignite Modification Date:
2025-12-24 @ 11:36 PM
NCT ID:
NCT04507256
Brief Summary:
In this first-in-humans dose escalation study, AZD7442 (AZD8895 + AZD1061) will be evaluated for safety, tolerability, pharmacokinetics, and generation of anti-drug antibodies (ADAs). The study is intended to enable future studies of AZD7442's efficacy in preventing and treating COVID-19.
Detailed Description:
This is a Phase I, first time in human, randomised, double-blind, placebo-controlled, and dose escalation study.
The study will comprise of:
1. A Screening Period of up to 27 days (Day -28 through Day -2);
2. A Treatment Period during which participants will be resident at the Clinical Unit from Day -1, 1 day before Investigational Medicinal Product (IMP) administration (on Day 1) until at least 24 hours after IMP administration, will be discharged on Day 2 after all safety evaluations have been completed, and
3. A Follow up Period lasting 360 days (through to Day 361) after the IMP dose.
The study will be conducted at a single study centre in United Kingdom.
Study:
NCT04507256
Study Brief:
Protocol Section:
NCT04507256