Description Module
The Description Module contains narrative descriptions of the clinical trial, including a brief summary and detailed description. These descriptions provide important information about the study's purpose, methodology, and key details in language accessible to both researchers and the general public.
Description Module path is as follows:
Study -> Protocol Section -> Description Module
Description Module
Ignite Creation Date:
2025-12-24 @ 11:10 PM
Ignite Modification Date:
2025-12-24 @ 11:10 PM
NCT ID:
NCT03520569
Brief Summary:
The investigators are studying the effects of Hyperglycemia on vascular function and insulin sensitivity on healthy adults
Detailed Description:
The investigators will study 22 healthy subjects (18-35 yrs) four times as follows:
1. Saline + Octreotide + euglycemia;
2. Octreotide + hyperglycemia;
3. Octreotide + hyperglycemia + insulin clamp and
4. Octreotide + Euglycemia + insulin clamp.
The sequence of admissions will be assigned randomly. The investigators will assess function in conduit (pulse wave velocity-PWV, augmentation index-AI and flow-mediated dilation-FMD), resistance (post-ischemic flow velocity-PIFV) and heart and skeletal muscle microvascular (contrast enhanced ultrasound-CEU) vessels.
This work will:
a) identify whether vascular stiffness and indices of NO action are impaired throughout the arterial tree with hyperglycemia.
Study:
NCT03520569
Study Brief:
Protocol Section:
NCT03520569