Description Module
The Description Module contains narrative descriptions of the clinical trial, including a brief summary and detailed description. These descriptions provide important information about the study's purpose, methodology, and key details in language accessible to both researchers and the general public.
Description Module path is as follows:
Study -> Protocol Section -> Description Module
Description Module
Ignite Creation Date:
2025-12-24 @ 10:41 PM
Ignite Modification Date:
2025-12-24 @ 10:41 PM
NCT ID:
NCT07276035
Brief Summary:
The goal of this study is to determine whether stimulation of the brain-stomach connection can influence stomach activity in healthy adults and in individuals suffering from chronic nausea. The main questions it aims to answer are:
* What are the best brain sites to influence the stomach?
* What are the effects of different stimulation patterns on stomach activity?
* Does the stimulation affect the sensation of nausea in participants suffering from chronic nausea?
Researchers will use a non-invasive method of brain stimulation called Transcranial Magnetic Stimulation (TMS) and will record stomach responses with skin electrodes on the abdomen.
Participants will:
* Visit the clinic at least once, and for up to 9 times more over the course of several months.
* Receive TMS while sitting in a chair similar to a dentist's chair.
* Drink water or consume a test meal during each study visit.
Detailed Description:
This study will use cutaneous recordings of stomach activity (electrogastrogram, EGG) and non-invasive brain stimulation with Transcranial Magnetic Stimulation (TMS) to
1. map descending cerebral cortical-to-stomach circuitry via gastric motor-evoked potentials (GMEPs),
2. use repetitive TMS (rTMS) applied to GMEP hotspots to modulate the stomach response to a satiety task (water load or nutrient drink/meal),
3. assess differences in topography and function of cortical-to-stomach circuitry between healthy subjects and subjects suffering from chronic nausea vomiting syndrome (CNVS).
Some clinical, demographic, and autonomic data (i.e. EKG) will be recorded and used as covariates to investigate any systematic impact on the outcome measures.
Study:
NCT07276035
Study Brief:
Protocol Section:
NCT07276035