Description Module
The Description Module contains narrative descriptions of the clinical trial, including a brief summary and detailed description. These descriptions provide important information about the study's purpose, methodology, and key details in language accessible to both researchers and the general public.
Description Module path is as follows:
Study -> Protocol Section -> Description Module
Description Module
Ignite Creation Date:
2025-12-24 @ 1:12 PM
Ignite Modification Date:
2025-12-24 @ 1:12 PM
NCT ID:
NCT07043595
Brief Summary:
This study aims to investigate how standing posture and mechanical loading affect reflex responses in the lower limb. Specifically, it focuses on the H-reflex-a type of spinal cord reflex-and how it changes during quiet standing and whole-body vibration. Ten healthy adult volunteers will participate. Researchers will record electrical responses from the calf muscle (soleus) while participants stand still or are exposed to gentle vibration. The goal is to better understand how the nervous system and skeletal system interact in regulating balance and movement.
Detailed Description:
This study investigates the neural mechanisms responsible for suppression of the H-reflex-a spinal monosynaptic reflex-during mechanical loading in the standing position. Previous research has shown that H-reflex amplitude decreases with increasing postural demand, such as during walking or standing compared to lying down. One hypothesis suggests that this suppression may be mediated not only by vestibular and cutaneous afferents, but also by a bone-derived reflex mechanism called the Bone Myoregulation Reflex (BMR).
In this study, 10 healthy adult volunteers will undergo H-reflex measurements while standing in various loading conditions, including quiet standing and during whole-body vibration (WBV). Participants will stand with one foot isolated from vibration while the other foot is on a vibrating platform. H-reflexes will be recorded from the soleus muscle using standard surface electromyography.
The primary aim is to determine whether BMR contributes to H-reflex suppression during loading. The findings may provide insight into the interaction between skeletal loading and spinal reflex modulation, with potential relevance to balance, gait, and rehabilitation science.
Study:
NCT07043595
Study Brief:
Protocol Section:
NCT07043595