Description Module
The Description Module contains narrative descriptions of the clinical trial, including a brief summary and detailed description. These descriptions provide important information about the study's purpose, methodology, and key details in language accessible to both researchers and the general public.
Description Module path is as follows:
Study -> Protocol Section -> Description Module
Description Module
Ignite Creation Date:
2025-12-24 @ 7:13 PM
Ignite Modification Date:
2025-12-24 @ 7:13 PM
NCT ID:
NCT00585403
Brief Summary:
The goal of this research is to determine how the peripheral immune system is altered by exercise and differences related to gender, pubertal status and health.
Detailed Description:
SPECIFIC AIMS:
1. To systematically measure for the first time in healthy children and adolescents the effects of brief bouts of exercise on:
1. Numbers of circulating PMBCs, their subsets and key intercellular adhesion molecules (ICAMs).
2. PBMC gene regulation of stress, inflammatory, and growth/repair mediators \[including: interleukin-4 (IL-4), IL-6, IL-10, tumor necrosis factor-alpha (TNF-alpha), interferon-gamma), growth hormone (GH), insulin-like growth factor-I (IGF-I), heat shock proteins (Hsp)\].
3. Circulating (serum) and intracellular PBMC levels of key mediators by flow cytometry and cell culture techniques.
4. Circulating endogenous triggers of PBMC mediator responses-soluble Hsp, IL-6, and F2-isoprostanes.
2. To determine how the acute PBMC responses are altered by gender, pubertal status, body composition (measured by whole-body and regional DEXA), and fitness (measured by progressive cycle ergometry and gas exchange).
3. To determine the relationship in healthy children and adolescents among acute PBMC responses to exercise, biochemical precursors of the metabolic syndrome (insulin, glucose, lipids), and the balance of the TH1/TH2 immune response.
Study:
NCT00585403
Study Brief:
Protocol Section:
NCT00585403