Description Module
The Description Module contains narrative descriptions of the clinical trial, including a brief summary and detailed description. These descriptions provide important information about the study's purpose, methodology, and key details in language accessible to both researchers and the general public.
Description Module path is as follows:
Study -> Protocol Section -> Description Module
Description Module
Ignite Creation Date:
2025-12-24 @ 5:42 PM
Ignite Modification Date:
2025-12-24 @ 5:42 PM
NCT ID:
NCT02587468
Brief Summary:
GOAL To identify absorption kinetics and bioavailability of phenolic compounds and specific vitamins from encapsulated Juice Plus+® powder
ENDPOINTS
* Absorption kinetics of phenolic compounds in plasma
* Bioavailability of vitamins C, E, and carotenoids into plasma
Subjects: 20 healthy subjects from Graz region, meeting all inclusion criterions (see underneath).
Detailed Description:
Phytonutrients are regarded to play an important role in many health-related issues like:
* Improvement of redox balance
* Anti-inflammatory effects
* Prevention of chronic diseases like CVD, stroke, diabetes II, Alzheimer´s, AMD, and certain forms of cancer
* Beneficial effects on human´s microbiome Therefore it is of scientific interest whether this product provides absorbable phytonutrients/phenolics and vitamins to support mechanistic explanations for the beneficial outcomes observed in the past after intake of Juice Plus+®.
GOAL To identify absorption kinetics and bioavailability of phenolic compounds and specific vitamins from encapsulated Juice Plus+® powder
MERITS
* This study would reveal knowledge whether and to which extent specific vitamins and phenolic compounds are absorbed, including absorption kinetics/metabolism.
* Data of this study may provide support for mechanistic arguments on the beneficial clinical outcomes observed and published in the past.
ENDPOINTS
* Absorption kinetics of phenolic compounds in plasma
* Bioavailability of vitamins C, E, and carotenoids into plasma
Absorption kinetics of phytonutrients:
* Open-, one-arm study, absorption kinetics over 10 hours
* 5 blood sample collections: baseline (= 0); 1hr, 2hrs, 5hrs and 10 hours after intake of 3 capsules
* Wash-out of all food supplements and dietetic foodstuff: 2 weeks
* Wash-out of phytonutrients: 48 hours before baseline sampling, accomplished via a phytonutrient-poor diet.
Bioavailability of vitamins C, E, A and carotenoids:
* Open-, one-arm study over 8 weeks
* 2 blood sample collections: at baseline (2 weeks after the phenolics experiment) and after 8-weeks
* Wash-out of all food supplements and dietetic foodstuff: 4 weeks, 2 weeks before the phenolics experiment + another 2 weeks Subjects: 20 healthy subjects from Graz region, meeting all inclusion criterions (see underneath).
Study:
NCT02587468
Study Brief:
Protocol Section:
NCT02587468