Description Module
The Description Module contains narrative descriptions of the clinical trial, including a brief summary and detailed description. These descriptions provide important information about the study's purpose, methodology, and key details in language accessible to both researchers and the general public.
Description Module path is as follows:
Study -> Protocol Section -> Description Module
Description Module
Ignite Creation Date:
2026-03-26 @ 3:18 PM
Ignite Modification Date:
2026-03-26 @ 3:18 PM
NCT ID:
NCT07418658
Brief Summary:
The UPWARD study is a prospective hypothesis-generating study in individuals with untreated Parkinson's disease (PD) and age-matched healthy controls (HCs). The objective of the study is to characterise disease-driven gastrointestinal (GI) changes that occur prior to initiation of treatment.
The main questions this study aims to answer are:
1. Are there changes in duodenal permeability in people with untreated PD?
2. Are there changes in the gut microbiome in people with untreated PD?
3. Are these gut changes linked to prodromal features, or movement and non-movement symptoms of PD?
The study consists of a screening visit, followed by a six-day home phase and one subsequent study visit at UZ Leuven. During the home phase, participants collect a stool sample, ingest radiopaque markers to assess gut transit time, and complete questionnaires. During the study visit, participants undergo an abdominal X-ray, a clinical assessment, and blood sampling. An upper GI endoscopy with duodenal biopsies is offered as an optional component of the study.
This study does not test a therapeutic intervention. Examinations as part of the study are not standard clinical care. The findings are expected to improve understanding of early GI involvement in PD and to inform future mechanistic and clinical research.
Detailed Description:
This is a hypothesis-generating study aimed at characterising gut microbiome composition and intestinal permeability in patients with drug-naïve Parkinson's disease (PD), compared to age-matched healthy controls (HCs). Drug-naïve PD patients and HCs will be prospectively recruited. After a screening visit, participants will undergo a single study visit; no longitudinal follow-up is planned.
Participants will undergo standardized assessments across five domains: (1) gut microbiome and fecal read-outs, (2) duodenal barrier function assessed using optional duodenal biopsies, (3) whole-gut transit time measured with radiopaque markers, (4) clinical features assessed using validated questionnaires and rating scales, and (5) laboratory parameters obtained from blood sampling.
For the main study procedures (stool collection, radiopaque pellet ingestion with abdominal X-ray, clinical assessments, questionnaires, and blood sampling), approximately 75 drug-naïve PD patients will be included. Approximately one third are expected to consent to the optional gastroduodenoscopy, resulting in an estimated subgroup of 25 PD patients with duodenal biopsies. Age-matched healthy controls will be recruited in comparable numbers for the respective study components. All analyses will be cross-sectional.
Study:
NCT07418658
Study Brief:
Protocol Section:
NCT07418658