Description Module
The Description Module contains narrative descriptions of the clinical trial, including a brief summary and detailed description. These descriptions provide important information about the study's purpose, methodology, and key details in language accessible to both researchers and the general public.
Description Module path is as follows:
Study -> Protocol Section -> Description Module
Description Module
Ignite Creation Date:
2026-03-26 @ 3:14 PM
Ignite Modification Date:
2026-03-26 @ 3:14 PM
NCT ID:
NCT07324395
Brief Summary:
The goal of this clinical trial is to learn how delayed onset muscle soreness (DOMS) in the calf muscle (gastrocnemius) affects the muscles of the posterior chain and physical performance in healthy young adults. The main questions the study aims to answer are:
Does DOMS in the calf muscle change the biomechanical properties (tone, stiffness, elasticity) of other muscles in the posterior chain?
Does DOMS lower trunk endurance, muscle strength, balance, or jump performance?
Participants will:
Take part in a gastrocnemius exercise protocol designed to safely create DOMS
Complete repeated assessments at baseline, immediately after exercise, and at 24, 48, and 72 hours
Have their muscle properties measured with a handheld device
Complete trunk endurance tests, muscle strength tests, balance tests, and a vertical jump test
Provide a blood sample to measure creatine kinase (a marker of muscle damage)
This research may help clinicians better understand how soreness in one muscle can influence the whole posterior chain and may guide safer training and recovery strategies.
Detailed Description:
This prospective repeated-measures clinical trial includes healthy adults aged 18-25 years. DOMS will be induced using a standardized exercise protocol targeting the gastrocnemius muscle. Outcome measures will be collected at five time points: baseline, immediately after the DOMS-inducing exercise, and 24, 48, and 72 hours post-exercise.
Primary outcomes include muscle biomechanical properties such as muscle tone, stiffness, elasticity, relaxation, and creep, measured using a digital myotonometer. Trunk endurance is also assessed as a primary outcome because of the posterior chain's role in load transfer and stabilization.
Secondary outcomes include:
Muscle strength
Dynamic balance performance
Vertical jump height
Pain pressure threshold
Serum creatine kinase levels to confirm muscle damage
To reduce assessment bias, each assessor is responsible for only one measurement type and is blinded to the DOMS-induction procedure. All assessments occur at the same time points for all participants.
The study aims to provide new information about how localized muscle soreness affects chain-related muscle behavior and functional performance. Findings may contribute to improved injury-prevention, training, and rehabilitation strategies, especially for populations exposed to high mechanical load.
Study:
NCT07324395
Study Brief:
Protocol Section:
NCT07324395