Description Module
The Description Module contains narrative descriptions of the clinical trial, including a brief summary and detailed description. These descriptions provide important information about the study's purpose, methodology, and key details in language accessible to both researchers and the general public.
Description Module path is as follows:
Study -> Protocol Section -> Description Module
Description Module
Ignite Creation Date:
2025-12-25 @ 5:01 AM
Ignite Modification Date:
2025-12-25 @ 5:01 AM
NCT ID:
NCT01572818
Brief Summary:
The purpose of this study is to evaluate efficacy of phlebotomy on insulin sensitivity as evaluated by euglycemic-hyperinsulinic clamp in insulin resistance-associated hepatic iron overload patients.
Detailed Description:
The main objective of this study is to evaluate in patients with HSD effects of treatment with phlebotomy rules with lifestyle and dietary rules versus lifestyle modifications alone on peripheral insulin resistance (assessed by hyperinsulinemic clamp).
Secondary objectives are:
* to study in all patients with HSD the relationship between the amount of iron intrahepatic and degree of peripheral insulin resistance and liver before therapeutic intervention.
* to study and compare the effects of phlebotomy treatment versus no treatment on:
* Plasma levels of adipocytokines,
* Plasma concentrations of inflammatory markers and markers of insulin resistance,
* The serum ferritin,
* The post-hepatic clearance of insulin,
* The surface of the abdominal visceral fat and subcutaneous abdominal.
Study:
NCT01572818
Study Brief:
Protocol Section:
NCT01572818